Not possible. For us, it would just slow down gameplay in a way that we don't want. But I can see why you might want this feature for a slower paced game/mod.

Enemies can drop 'chests' / 'lootboxes' / random loot reward items though. I'm not sure that is what you are looking for but items can render with sprites on the ground and having a ~'rusty box' with ground sprite and inventory icon art is possible. It is just that I think that once it is opened the random loot box is removed and the random items try to populate / go in the inventory. Almost like the character just dumps it out in the inventory and throws the box away X-P.

Thank you for the perspective sharing. I hope your project hums along nicely. Is this one of many or kind of new?